Bisocam 2.5/52.5mg+5mg
Type:10 Tablets
Generic Name:Bisoprolol + Amlodipine
Manufacturer:Square Pharmaceuticals PLC.
Price:৳80.00
Indication
Treatment of mild to moderate hypertension
Adult Dose
Oral Adult 1 tablet once daily
Contraindication
Cardiogenic shock, overt cardiac failure, second or third degree AV block, and marked sinus bradycardia and known sensitivity to amlodipine/bisoprolol.
Mode of Action
Bisoprolol selectively and competitively blocks β1-receptors but has little or no effect on β2-receptors except at high doses. Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.
Precaution
Bisoprolol: Overt congestive cardiac failure, abrupt cessation of therapy, peripheral vascular disease, bronchospastic disease, anesthesia and major surgery, diabetes and hypoglycaemia and thyrotoxicosis. Amlodipine: Severe aortic stenosis, congestive heart failure and hepatic failure This medicine is not recommended for use in breastfeeding women unless absolutely necessary.
Side Effect
Edema, headache, increase heart rate, sneezing, fatigue, leg cramps, dry mouth. Other adverse events reported were gastric irritation, angina, asthma, cold extremities, cough, decrease in libido, dizziness, facial flushing, postural hypotension, skin rash, sleep disturbance and vertigo.
