Simplovir5%
Type:5gm tube
Generic Name:Acyclovir 5% Topical
Manufacturer:Incepta Pharmaceuticals Ltd.
Price:৳40.00
Indication
As 5% oint/cream: Apply to the affected skin 5-6 times/day for 5-10 days.
Administration
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Adult Dose
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.
Renal Dose
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Precaution
Herpes virus infections of skin
Pregnancy Category Note
>10% Burning/stinging (30%) 1-10% Pruritus (4%) <1% Dry lips (<1%),Rash (0.3%) Frequency Not Defined Angioedema,Vulvitis
Interaction
Hypersensitivity.
