Arimidex1mg
Type:10 Tablets
Generic Name:Anastrozole
Manufacturer:ACI Limited
Price:৳500.00
Indication
Oral Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr. Hepatic Impairment Mild-to-moderate impairment or stable hepatic cirrhosis: Dose adjustment not necessary Severe hepatic impairment: Not studied
Administration
Efficacy decreased by oestrogens. Plasma concentrations decreased by tamoxifen.
Adult Dose
Moderate or severe hepatic impairment, hyperlipidaemias. Laboratory test for menopause if status is doubtful. Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter. Lactation: Unknown whether drug is excreted in milk; not recommended given potential for serious adverse reactions in nursing infants
Renal Dose
Anastrozole prevents conversion of androstenedione to estrone and testosterone to oestradiol by inhibiting aromatase, thus leading to significantly reduced serum oestradiol concentrations.
Mode of Action
May be taken with or without food.
Precaution
Breast cancer, Ovulation induction
Pregnancy Category Note
>10% Hot flashes (12-36%),Vasodilation (25-36%),Fatigue (19%),Mood disturbances (19%),Nausea and vomiting (19%),Weakness (16-19%),Arthritis (17%),Pain (17%),Arthralgia (2-15%),Pharyngitis (14%),Depression (13%),Hypertension (2-13%),Bone pain (11%),Increased cough (11%),Osteoporosis (11%),Rash (8-11%) 1-10% Accidental injury (10%),Back pain (10%),Fracture (10%),Headache (10%),Insomnia (10%),Peripheral edema (10%),Dyspnea (8-10%),Abdominal pain (9%),Infection (9%),Lymphedema (9%),Diarrhea (8-9%),Constipation (7-9%),Breast pain (8%),Dizziness (8%),Urinary tract infection (8%),Chest pain (7%),Dyspepsia (7%),Paresthesia (5-7%),Anxiety (6%),Cataracts (6%),Flu syndrome (6%),Sinusitis (6%),Vulvovaginitis (6%),Xerostomia (6%),Breast neoplasm (5%),Bronchitis (5%),Cyst (5%),Diaphoresis (5%),Neoplasm (5%),Vaginal bleeding (5%),Fractures of spine, hip, or wrist (4%),Ischemic cardiovascular disease (4%),Vaginal hemorrhage (4%),Vaginitis (4%),Leukorrhea (3-4%),Deep vein thrombosis (2%),Endometrial cancer (intact uterus at baseline) (2%),Ischemic cerebrovascular event (2%),Weight gain (2%),Lethargy (1%)
Interaction
Pregnancy. Hypersensitivity, premenopausal women.
