This 2026 AHA/ACC/ADA/ASN clinical practice guideline provides comprehensive, evidence-based recommendations for the prevention, detection, evaluation, and management of cardiovascular-kidney-metabolic (CKM) syndrome. It emphasizes early risk assessment, lifestyle modification, interdisciplinary care, weight management, and the use of cardioprotective and kidney-protective therapies to reduce cardiovascular and renal complications. The guideline is intended to support cardiologists, endocrinologists, nephrologists, primary care physicians, and other healthcare professionals in delivering coordinated, patient-centered care across the CKM spectrum.